17-Hydroxyprogesterone, Serum

17 Alphahydroxyprogesterone; 17 Hydroxy Progesterone, Serum; Hydroxyprogesterone; Progesterone, 17-Hydroxy

Useful for:

• The analysis of 17-hydroxyprogesterone (17-OHPG) is 1 of the 3 analytes along with cortisol and androstenedione, that constitutes the best screening test for congenital adrenal hyperplasia (CAH), caused by either 11- or 21-hydroxylase deficiency


• Analysis for 17-OHPG is also useful as part of a battery of tests to evaluate females with hirsutism or infertility; both can result from adult-onset CAH


• See Steroid Pathways for additional information

Serum

Red top tube

0.25 mL

Indicate patient's age and sex

• Refrigerated (preferred): 14 days


• Frozen: 28 days


• Ambient: 7 days

• Gross hemolysis


• Gross lipemia


• Serum Gel (SST)

At birth the hypothalamic-pituitary-adrenal axis and the hypothalamic-pituitary-gonadal axis are activated and adrenal and sex steroid levels are high. In preterm infants the elevations can be even more pronounced due to illness and stress. As a result, preterm infants may occasionally have 17-hydroxyprogesterone levels of up to 1,000 ng/dL. Term infants (0-28 days) will have levels <630 ng/dL. These then fall over the following 1 to 6 months to prepubertal levels of <110 ng/dL (males) and <100 ng/dL (females).

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

2-5 days

Monday-Friday

83498

*Levels fall from newborn to prepubertal gradually within 6 months.

Mayo

1668-3

Test Definition: OHPG

Steroid Pathways