Alpha-Fetoprotein (AFP), Single Marker Screen, Maternal, Serum

AFP Maternal Screening, AFP Neural Tube Defects, Maternal Screening, AFP Single Marker

Prenatal screening for open neural tube defect
HIGHLIGHTS
This test is a screening assay to identify pregnancies that may have an increased risk for neural tube defects (NTD).
 A-positive result indicates that the calculated alpha-fetoprotein multiple of the median (MoM) is 2.50 or greater and may indicate an increased risk for NTD.
A screen-positive result does not infer a definitive diagnosis of a NTD but indicates that further evaluation should be considered.

SST

Serum

1 mL

Red Top Serum

1. Do not collect specimen after amniocentesis as this could affect results.

2. Centrifuge and aliquot serum into plastic vial within 2 hours of collection.

Additional Information:

1. Collect blood between 15 weeks, 0 days and 22 weeks, 6 days.

2. Initial or repeat testing is determined in the laboratory at the time of report and will be reported accordingly. To be considered a repeat test for the patient, the testing must be within the same pregnancy and trimester, with interpretable results for the same test, and both tests are performed at Mayo Clinic.

0.5 mL

1. Second Trimester Maternal Screening Alpha-Fetoprotein / Quad Screen Patient Information (T595) is required

2. If not ordering electronically, complete, print, and send a General Request (T239)

Refrigerated (preferred) 14 days
Frozen 90 days
Ambient 7 days 

Gross hemolysis

Two-Site Immunoenzymatic (Sandwich) Assay

4-6 Days

Monday - Friday

IDD Insulin dependent diabetes 44877-9
IVFP IVF pregnancy 47224-1
MULTF Number of Fetuses 55281-0
10356 INTERPRETATION 49092-0
10248 Additional comments 48767-8
10357 RECOMMENDED FOLLOW UP 80615-8
10358 GENERAL TEST INFORMATION 62364-5
7058 Recalculated Maternal Serum Screen 32399-8
3009 Specimen collection date 33882-2
7823 Maternal date of birth 21112-8
7834 Calculated age at EDD 43993-5
26717 Maternal Weight 29463-7
26718 Maternal Weight 29463-7
10054 EDD by U/S scan 11781-2
7753 EDD by LMP 11779-6
7203 GA on collection by U/S scan 11888-5
7204 GA on collection by dates 11885-1
7830 GA used in risk estimate 21299-3
10351 AFP 83073-7
113146 Results Summary 32399-8
113147 Neural tube defect risk estimate 48803-1
113148 AFP MoM 23811-3
RACE1 Patient race 21484-1
SMKNG Current cigarette smoking status 64234-8
CHOR_ Number of Chorions 92568-5
PRNTD Prev Pregnancy w/ Neural Tube Defect 53827-2
PTNTD Patient or father of baby has a NTD 53827-2
INTL Initial or repeat testing 77202-0
DRPHN Physician Phone Number 68340-9

6 months

82105

NEURAL TUBE DEFECTS:

An alpha-fetoprotein (AFP) multiple of the median (MoM) <2.5 is reported as screen negative.

AFP MoM > or =2.5 (singleton and twin pregnancies) are reported as screen positive.

An interpretive report will be provided.

No

Mayo

48802-3